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Ethylene glycol (IUPAC name: ethane-1,2-diol) is an organic compound with the formula (CH2OH)2. It is mainly used for two purposes, as a raw material in the manufacture of polyester fibers and for antifreeze formulations. It is an odorless, colorless, sweet-tasting, viscous liquid. Ethylene glycol is moderately toxic.

This reaction can be catalyzed by either acids or bases or can occur at neutral pH under elevated temperatures. The highest yields of ethylene glycol occur at acidic or neutral pH with a large excess of water. Under these conditions, ethylene glycol yields of 90% can be achieved. The major byproducts are the oligomers diethylene glycol, triethylene glycol, and tetramethylene glycol. The separation of these oligomers and water is energy-intensive. About 6.7 million tonnes are produced annually.

Uses
Ethylene glycol is primarily used in antifreeze formulations (50%) and as a raw material in the manufacture of polyesters such as polyethylene terephthalate (PET) (40%).

Coolant and heat-transfer agent
The major use of ethylene glycol is as a medium for convective heat transfer in, for example, automobiles and liquid-cooled computers. Ethylene glycol is also commonly used in chilled-water air-conditioning systems that place either the chiller or air handlers outside or systems that must cool below the freezing temperature of water. In geothermal heating/cooling systems, ethylene glycol is the fluid that transports heat through the use of a geothermal heat pump. The ethylene glycol either gains energy from the source (lake, ocean, water well) or dissipates heat to the sink, depending on whether the system is being used for heating or cooling.

Pure ethylene glycol has a specific heat capacity about one half that of water. So, while providing freeze protection and an increased boiling point, ethylene glycol lowers the specific heat capacity of water mixtures relative to pure water. A 1:1 mix by mass has a specific heat capacity of about 3140 J/(kg·°C) (0.75 BTU/(lb·°F)), three quarters that of pure water, thus requiring increased flow rates in same system comparisons with water. The formation of large bubbles in cooling passages of internal combustion engines will seriously inhibit heat flow (flux) from that area, thus allowing nucleation (tiny bubbles) heat transfer to occur is not advisable. Large bubbles in cooling passages will be self-sustaining or grow larger, with virtually the complete loss of cooling in that spot. With pure MEG that hot spot has to get to 200 °C (392 °F). Cooling due to other effects such as air draft from fan etc. (not considered in pure nucleation analysis) will assist in preventing large-bubble formation.